Yanowitz Research Group
Principal Investigator:
Judith Yanowitz, PhD
The Yanowitz lab aims to elucidate the mechanisms that underlie human reproductive aging. Defects in meiotic crossover recombination are a major determinant of chromosome mis-segregation during the formation of eggs and sperm.
The lab addresses how meiosis is regulated using the nematode C. elegans, where the combination of genetic, molecular, and cytological tools facilitates the isolation and characterization of meiotic genes.
Lab Members
Olivia McGovern, BS
Selected Publications
- Wagner CR, Kuervers L, Baillie D, & Yanowitz JL. Xnd-1 regulates the global recombination landscape in C. elegans. Nature, 467(7317): 839-43, Oct. 14, 2010.
- Yanowitz J. Meiosis: Making a break for it. Current Opinion in Cell Biology, 22(6):744-51, Dec. 2010.
- Lim JG, Stine RR, & Yanowitz J. Domain-specific regulation of recombination in C. elegans in response to temperature age, and sex. Genetics, 180(2):715-26, 2008. *Issue highlight
- Yanowitz J. Genome integrity is regulated by the C. elegans Rad51D homolog, rfs-1. Genetics, 179(1):249-62, 2008.
- Ward JD, Barber LJ, Petalcorin MIR, Yanowitz J, & Boulton SJ. Replication blocking lesions present a unique substrate for homologous recombination. Embo J, 26(14): 3384-96, 2007.
- Yanowitz J & Fire AZ. Cyclin D involvement demarcates a late transition in C. elegans embryogenesis. Dev Biol, 279(1):244-51, 2005.
- Yanowitz J, Shakir MA, Hedgecock E, Fire AZ, & Lundquist EA. UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation. Dev Biol, 272(2): 389-402, 2004.